migraine awareness group
migraines.orgnational migraine associationmigraineur
about magnum
migraine news
migraine myths
migraine disability
migraine treatment
migraine help
migraine faqs
search
sponsors
home

treatment & management

Drug Profiles:
hydroxyzine
AKA Vistaril®

Description
Some of the antihistamines are also used to prevent motion sickness, nausea, vomiting, and dizziness. Hydroxyzine is often used to treat the nausea and vomiting and, to some extent, the pain associated with a Migraine attack. It also allows the Migraineur to rest more easily and allows other medications to work better.

Oral

  • Capsules (U.S. and Canada)
  • Tablets (U.S.)
  • Oral Suspension (U.S.)
  • Syrup (U.S. and Canada)

Parenteral

  • Injection (U.S. and Canada)
   

Before Using This Medicine
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For lithium, the following should be considered:

Allergies-
Tell your doctor if you have ever had any unusual or allergic reaction to antihistamines. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.

Diet-
Make certain your health care professional knows if you are on a low-sodium, low-sugar, or any other special diet. Most medicines contain more than their active ingredient, and many liquid medicines contain alcohol.

Pregnancy-
Not enough studies have been done in humans to determine metoclopramide's safety during pregnancy. However, metoclopramide has not been shown to cause birth defects or other problems in animal studies.

Breast-feeding-
Mmall amounts of antihistamines pass into the breast milk. Use is not recommended since babies are more susceptible to the side effects of antihistamines, such as unusual excitement or irritability. Also, since these medicines tend to decrease the secretions of the body, it is possible that the flow of breast milk may be reduced in some patients.

Children-
Serious side effects, such as convulsions (seizures), are more likely to occur in younger patients and would be of greater risk to infants than to older children or adults. In general, children are more sensitive to the effects of antihistamines. Also, nightmares or unusual excitement, nervousness, restlessness, or irritability may be more likely to occur in children.

Older adults-
Elderly patients are usually more sensitive to the effects of antihistamines. Confusion; difficult or painful urination; dizziness; drowsiness; feeling faint; or dryness of mouth, nose, or throat may be more likely to occur in elderly patients. Also, nightmares or unusual excitement, nervousness, restlessness, or irritability may be more likely to occur in elderly patients.

Other medicines-
Always tell your doctor all medications you are taking, both prescription and over-the-counter. Although certain medicines should not be used together at all, in other cases different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking antihistamines it is especially important that your health care professional knows if you are taking any of the following:

  • Anticholinergics (medicine for abdominal or stomach spasms or cramps)—Side effects, such as dryness of mouth, of antihistamines or anticholinergics may be more likely to occur
  • Clarithromycin (e.g., Biaxin)
  • Erythromycin (e.g., E-Mycin)
  • Itraconazole (e.g., Sporanox)
  • Ketoconazole (e.g., Nizoral)
  • Troleandomycin—Use of these medicines with astemizole or terfenadine may cause heart problems, such as an irregular heartbeat; these medicines should not be used together.
  • Bepridil (e.g., Vascor)
  • Disopyramide (e.g., Norpace)
  • Maprotiline (e.g., Ludiomil)
  • Phenothiazines (acetophenazine [e.g., Tindal], chlorpromazine [e.g., Thorazine], fluphenazine [e.g., Prolixin], mesoridazine [e.g., Serentil], perphenazine [e.g., Trilafon], prochlorperazine [e.g., Compazine], promazine [e.g., Sparine], promethazine [e.g., Phenergan], thioridazine [e.g. Mellaril], trifluoperazine [e.g., Stelazine], triflupromazine [e.g., Vesprin], trimeprazine [e.g., Temaril])
  • Pimozide (e.g., Orap)
  • Procainamide (e.g., Pronestyl)
  • Quinidine (e.g., Quinaglute Dura-tabs)
  • Central nervous system (CNS) depressants (medicines that cause drowsiness)—Effects, such as drowsiness, of CNS depressants or antihistamines may be worsened; also, taking maprotiline or tricyclic antidepressants may cause some side effects of either of these medicines, such as dryness of mouth, to become more severe
  • Cisapride (e.g., Propulsid)
  • HIV-protease inhibitors (indinavir [e.g., Crixivan], nelfinavir [e.g., Viracept], ritonavir [e.g., Norvir], saquinavir [e.g., Fortovase, Invirase]) or
    Mibefradil (e.g., Posicor)
  • Serotonin reuptake inhibitors (fluoxetine [e.g., Prozac], fluvoxamine [e.g., Luvox], nefazodone [e.g., Serzone], paroxetine [e.g., Paxil], sertraline [e.g., Zoloft])
  • Sparfloxacin (e.g., Zagam)
  • Zileuton (e.g., Zyflo)—Use of these medicines with astemizole or terfenadine may cause heart problems; these medicines should not be used with astemizole or terfenadine
  • Monoamine oxidase (MAO) inhibitors (furazolidone [e.g., Furoxone], isocarboxazid [e.g., Marplan], phenelzine [e.g., Nardil], procarbazine [e.g., Matulane], selegiline [e.g., Eldepryl], tranylcypromine [e.g., Parnate])—If you are now taking, or have taken within the past 2 weeks, any of the MAO inhibitors, the side effects of the antihistamines, such as drowsiness and dryness of mouth, may become more severe; these medicines should not be used together
  • Quinine—Use of this medicine with astemizole may cause heart problems, such as irregular heartbeat; these medicines should not be used together.

Other medical problems-
Make sure you tell your doctor if you have any other medical problems, especially:

  • Enlarged prostate or
  • Urinary tract blockage or difficult urination—Antihistamines may make urinary problems worse
  • Glaucoma—These medicines may cause a slight increase in inner eye pressure that may make the condition worse
  • Heart rhythm problems (history of)
  • Intestinal obstruction
  • Low potassium blood levels—Use of astemizole or terfenadine can cause serious heart rhythm problems
  • Liver disease—Higher blood levels of astemizole or terfenadine may result, which may increase the chance of heart problems
  • Stomach ulcer


Proper Use of This Medicine-

Other medical problems—The presence of other medical problems may affect the use of metoclopramide. Make sure you tell your doctor if you have any other medical problems, especially:

  • Abdominal or stomach bleeding
  • Asthma
  • High blood pressure
  • Intestinal blockage
  • Mental depression
  • Parkinson's disease—Metoclopramide may make these conditions worse
  • Epilepsy—Metoclopramide may increase the risk of having a seizure
  • Kidney disease (severe)—Higher blood levels of metoclopramide may result, possibly increasing the chance of side effects

Proper use of this medicine-
Do not take larger doses or more often than recommended on the label, unless otherwise directed by your doctor. To do so may increase the chance of side effects .

Dosing-

  • For oral dosage forms (capsules, tablets, or liquid):
    • Adults: 25 to 100 milligrams (mg) three or four times a day as needed.
    • Children younger than 6 years of age: 12.5 mg every six hours as needed.
    • Children 6 years of age and older: 12.5 to 25 mg every six hours as needed.
  • For injection dosage form:
    • Adults: 25 to 100 milligrams (mg) injected into a muscle.
    • Children: 1 mg per kg (0.45 mg per pound) of body weight injected into a muscle. .

Missed dose-
If you are taking this medicine regularly and you miss a dose, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage-

  • Keep out of the reach of children.
  • Store away from heat and direct light.
  • Do not store the capsule or tablet form of this medicine in the bathroom medicine cabinet, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down.
  • Keep the liquid form of this medicine from freezing.
  • Do not keep outdated medicine or medicine no longer needed. Be sure that any discarded medicine is out of the reach of children.

Side Effects of This Medicine

Check with your doctor as soon as possible if any of the following side effects occur:

  • Less common or rare: Fast or irregular heartbeat; fever; abdominal or stomach pain; burning; chills; clay-colored stools or dark urine; cough; diarrhea; difficulty swallowing; dizziness; fast heartbeat; fever; headache; hives; itching; prickly sensations; puffiness or swelling of the eyelids or around the eyes, face, lips or tongue ; seizures; shortness of breath; skin rash; tightness in chest; tingling; unusual tiredness or weakness; wheezing; sore throat; unusual bleeding or bruising ; unusual tiredness or weakness

Some commonly used brand names are:

In the U.S.-

  • Atarax
  • Hyzine-50
  • Vistaril

In the U.S.-
 
  • Apo-Hydroxyzine
  • Multipax
  • Novo-Hydroxyin

 

 
703.739.9384
Information offered at this Web site by either a lay person or a health professional should not be interpreted as giving a diagnosis or a treatment recommendation. These can only be provided by a physician who has had an opportunity to interact with a patient in person and at length, with access to the patient's previous records and appropriate follow-up.