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Before Using This Medicine
In deciding to use a medicine, the
risks of taking the medicine must be weighed against the good it will
do. This is a decision you and your doctor will make. For lithium, the
following should be considered:
Allergies-
Tell your doctor if you have ever had any unusual or allergic
reaction to trimethobenzamide, or if you are allergic or sensitive to
benzocaine or other local anesthetics (the suppository form of this
medicine contains benzocaine). Also tell your health care professional
if you are allergic to any other substances, such as foods,
preservatives, or dyes.
Pregnancy-
Studies have not been done in pregnant women. However, although
studies in animals have not shown that trimethobenzamide causes birth
defects, it has been shown to increase the chance of a miscarriage.
Breast-feeding-
It is not known whether trimethobenzamide passes into breast milk.
Although most medicines pass into breast milk in small amounts, many of
them may be used safely while breast-feeding. Mothers who are taking
this medicine and who wish to breast-feed should discuss this with their
doctor.
Children-
This medicine should not be used to treat nausea and vomiting in
children unless otherwise directed by your doctor. Some side effects may
be more serious in children.
Older adults-
Many medicines have not been studied specifically in older people.
Therefore, it may not be known whether they work exactly the same way
they do in younger adults or if they cause different side effects or
problems in older people. There is no specific information comparing use
of trimethobenzamide in the elderly with use in other age groups.
Other medicines-
Always tell your doctor all
medications you are taking, both prescription and over-the-counter.
Although certain medicines should not be used together at all, in other
cases two different medicines may be used together even if an
interaction might occur. In these cases, your doctor may want to change
the dose, or other precautions may be necessary. When you are using
trimethobenzamide, it is especially important that your health care
professional know if you are taking any of the following:
- Central nervous system (CNS)
depressants (medicine that causes drowsiness)
- Tricyclic antidepressants - Taking
these medicines with trimethobenzamide may cause increased CNS
depressant or other serious effects
Other medical problems-
Make sure you tell your doctor
if you have any other medical problems, especially:
- High fever
- Intestinal infection - Using
trimethobenzamide may result in serious side effects
Proper Use of This Medicine-
- Do not use this medicine to treat
nausea and vomiting in children unless otherwise directed by your
doctor. If you are giving this medicine to a child, be especially
careful not to give more than is prescribed since side effects may be
more serious in children.
- Trimethobenzamide is used only to
relieve or prevent nausea and vomiting. Use it only as directed. Do
not use more of it and do not use it more often than your doctor
ordered. To do so may increase the chance of side effects.
- To insert the rectal suppository
form of this medicine: First, remove foil wrapper and moisten the
suppository with cold water. Lie down on your side and use your finger
to push the suppository well up into the rectum. If the suppository is
too soft to insert, chill it in the refrigerator for 30 minutes or run
cold water over it before removing the foil wrapper. Wash your hands
with soap and water.
Dosing-
The dose of trimethobenzamide will be different for different patients.
Follow your doctor's orders or the directions on the label. The
following information includes only the average doses of
trimethobenzamide. If your dose is different, do not change it unless
your doctor tells you to do so.
The number of capsules that you take, or suppositories that you use,
depends on the strength of the medicine. Also, the number of doses you
take each day, the time allowed between doses, and the length of time
you take the medicine depend on the medical problem for which you are
taking trimethobenzamide.
- For oral dosage form (capsules):
- For nausea and vomiting:
- Adults and children 12 years of
age and older—250 milligrams (mg) three or four times a day as
needed.
- Children—Dose is based on body
weight and must be determined by your doctor. The usual dose is 15
mg per kilogram (6.8 mg per pound) of body weight divided into
three or four doses. The dose is usually not more than 200 mg
three or four times a day as needed.
- For injection dosage form:
- For nausea and vomiting:
- Adults and children 12 years of
age and older—200 mg three or four times a day as needed, injected
into a muscle.
- Children—Use is not recommended.
- For rectal dosage form
(suppositories):
- For nausea and vomiting:
- Adults and children 12 years of
age and older—200 mg three or four times a day as needed.
- Children—Dose is based on body
weight and must be determined by your doctor. The usual dose is 15
mg per kilogram (6.8 mg per pound) of body weight divided into
three or four doses. The dose is usually not more than 200 mg
three or four times a day as needed.
Missed dose-
If you must use this medicine regularly
and you miss a dose, use it as soon as possible. However, if it is
almost time for your next dose, skip the missed dose and go back to your
regular dosing schedule. Do not double doses.
Storage-
- Keep out of the reach of children.
- Store away from heat and direct
light.
- Do not store the capsule form of
this medicine in the bathroom, near the kitchen sink, or in other damp
places. Heat or moisture may cause the medicine to break down.
- Do not keep outdated medicine or
medicine no longer needed. Be sure that any discarded medicine is out
of the reach of children.
Precautions While Using This Medicine
- Trimethobenzamide will add to the
effects of alcohol and other CNS depressants (medicines that make you
drowsy or less alert). Some examples of CNS depressants are
antihistamines or medicine for hay fever, other allergies, or colds;
sedatives, tranquilizers, or sleeping medicine; prescription pain
medicine or narcotics; barbiturates; medicine for seizures; muscle
relaxants; or anesthetics, including some dental anesthetics. Check
with your doctor before taking any of the above while you are using
this medicine.
- This medicine may cause some people
to become dizzy, lightheaded, drowsy, or less alert than they are
normally. Make sure you know how you react to this medicine before you
drive, use machines, or do anything else that could be dangerous if
you are dizzy or are not alert.
- When using trimethobenzamide on a
regular basis, make sure your doctor knows if you are taking large
amounts of aspirin or other salicylates at the same time (as for
arthritis or rheumatism). Effects of too much aspirin, such as ringing
in the ears, may be covered up by this medicine.
Side Effects of This Medicine
Check with your doctor as soon as
possible if any of the following side effects occur:
- Rare: Body spasm, with head and
heels bent backward and body bowed forward; convulsions (seizures);
mental depression; shakiness or tremors; skin rash; sore throat or
fever; unusual tiredness; vomiting (severe or continuing); yellow eyes
or skin
Other side effects may occur that
usually do not need medical attention. These side effects may go away
during treatment as your body adjusts to the medicine. However, check
with your doctor if any of the following side effects continue or are
bothersome:
- More common: Drowsiness
- Less common: Blurred vision;
diarrhea; dizziness; headache; muscle cramps
Some commonly used brand names are:
In the U.S.-
- Benzacot
- Stemetic
- Tebamide
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- Tigan
- Tribenzagan
- Trimazide
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