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treatment & management

Drug Profiles:
Excedrin® Migraine

Product Background

  • Active ingredients: acetaminophen 200 mg, aspirin 250 mg, caffeine 65 mg
  • Purpose: Pain reliever
  • Use: Treats pain of mild Migraine.

It is essential when using NSAIDs such as aspirin and acetaminophen  for head pain that they not be taken too frequently or they can actually cause headaches referred to as "Rebound Headache." For more information about Rebound Headache, see:



  • Reye's syndrome: Children and teens should not use this drug for chicken pox or flu symptoms before a doctor is consulted about Reye's syndrome, a rare but serious illness reported to be associated with aspirin.
  • Allergy alert: aspirin may cause a sever allergic reaction which may include"
    • hives
    • facial swelling
    • asthma (wheezing)
    • shock
  • Alcohol warning: if you consume 3 or more alcoholic drinks every day, ask your doctor whether you should take ibuprofen or other pain relievers/fever reducers. Acetaminopehn and aspirin may cause stomach bleeding.
  • Caffeine warning: The recommended dose of this product contains about as much caffeine as a cup of coffee. Limit the use of caffeine-containing medications, foods, or beverages while taking this product because too much caffeine may cause nervousness, irritability, sleeplessness, and, occasionally, rapid heart beat.
  • Do not use if you have ever had an allergic reaction to any other pain reliever/fever ruducer.

Ask a doctor before use if you have:

  • never had Migraines diagnosed by a health professional
  • a Migraine episode that is different from your usual migraines
  • the worst headache of your life
  • fever and stiff neck
  • headaches beginning after or caused by head injury, exertion, coughing or bending
  • experienced your first headache after the age of 50
  • daily headaches
  • a Migraine so severe as to require bed rest
  • problems or serious side effects from taking pain relievers or fever reducers
  • stomach pain
  • vomiting with your Migraine

Ask a doctor or pharmacist before use if you are taking a prescription drug for:

  • anticoagulation
  • arthritis
  • diabetes
  • gout

Stop use and contact a doctor if:

  • an allergic reaction occurs. Seek medical help right away
  • Migraine pain is not relieved or gets worse after first dose
  • new or unexpected symptoms occur
  • ringing in the ears or hearing loss occurs

Pregnancy and breastfeeding:
Ask a health care professional before use. Because aspirin may cause problems to the unborn child or complications during delivery, it is especially important not to use aspirin during the last three months of pregnancy unless directed to do so by your physician.

Dosage & Directions:

  • Adults: take 1 with a glass of water
  • Do not take more than two tablets in 24 hours unless you are instructed to do so by your doctor
  • If symptoms persist or worsen, ask your doctor
  • Under 18 years of age: consult your doctor

Other Information:

  • Do not use if neck wrap or foil inner seal imprinted "Safety Seal" is broken or missing
  • Store at 20-25C° (68-77°F)
  • See end of panel for lot number and expiration date

Inactive Ingredients:

benzoic acid, carnuba was, hydroxypropylcellulose, hydroxypropyl methylcellulose, microcrystalline cellulose, mineral oil, polysorbate 20, povidone, propylene glycol, simethicone emulsion, sorbitan monolaurate, stearic acid, may also contain FD&C blue no. 1, titanium dioxide..